Smoking During Pregnancy, Lead Exposure Raise ADHD Risk in Kids

February 8th, 2010

Children whose mothers smoked during pregnancy or who were exposed to lead have more than double the risk of having attention-deficit hyperactivity disorder (ADHD) as other children, new research shows.

And with exposure to both cigarettes and lead, the chances of having ADHD soared. Children whose mothers smoked during pregnancy and whose blood showed signs of lead exposure had eight times the risk of having ADHD.

“When you have both exposures, there is a synergistic effect,” said study author Dr. Tanya Froehlich, a developmental and behavioral pediatric specialist and an assistant professor of pediatrics at Cincinnati Children’s Hospital Medical Center.

The researchers concluded that about 38 percent of ADHD cases among children aged 8 to 15 in the United States may be caused by prenatal exposure to tobacco smoke, while 25 percent of ADHD cases are due to lead exposure, according to the study in the Nov. 23 online issue of Pediatrics.

Froehlich and her colleagues used data on 2,588 children aged 8 to 15 from around the nation who took part in the 2001-2004 National Health and Nutrition Examination Survey. Tobacco exposure was assessed by asking mothers if they smoked during pregnancy, while lead concentrations were measured by a blood test.

About 8.7 percent of children met the criteria for ADHD, which is marked by inattentiveness, difficulty focusing, impulsivity and hyperactivity, according to the study. The ADHD group included 16.8 percent of children whose mothers smoked during pregnancy, compared to 6.6 percent of children whose mothers did not smoke.

Lead exposure was divided into three groups: low, medium and high. About 5.2 percent of children who had the lowest lead blood levels had ADHD. About 9.1 percent of children in the middle range had ADHD, while 13.6 percent of children in the highest third had ADHD, the researchers found.

About 28.6 percent of children who were exposed to both prenatal smoking and who had higher blood lead concentrations had ADHD, Froehlich said.

Researchers did not find a strong link between exposure to secondhand cigarette smoke during childhood and ADHD.

Alarmingly, even children in the upper third had lead exposure levels lower than what the federal government considers “elevated.” The U.S. Centers for Disease Control and Prevention considers levels of 10 micrograms per deciliter “actionable,” Froehlich said. In the study, children in the upper third had blood lead levels that were 1.3 micrograms per deciliter or greater; children in the middle group had levels between 0.9 and 1.3 micrograms per deciliter.

Previous research has shown lead is toxic to children’s brains and is associated with lower IQs and hyperactivity in children.

“There is no such thing as a ’safe’ level of lead,” said Dr. Andrew Adesman, chief of developmental and behavioral pediatrics at Schneider Children’s Hospital in New Hyde Park, N.Y. “We know the lower the lead level, the better. This is an interesting and important study in that it looks at the combined effects of lead and prenatal cigarette exposure.”

Though much remains unknown about the specific causes of ADHD, “we have long believed ADHD is at least in large part due to abnormalities of dopamine in the brain,” Adesman said. Previous research has shown lead exposure and cigarette smoking may alter the brain’s metabolism of dopamine.

About 250,000 U.S. children aged 1 to 5 have blood lead levels greater than 10 micrograms of lead per deciliter of blood, according to the CDC. Though blood lead levels have generally dropped in recent years, children, particularly those in poor, inner-city neighborhoods, may still be exposed to lead from peeling paint in old buildings. Leaded paint was banned for most residential uses in the United States in 1978.

Children may also ingest lead from old water pipes, soil and toys. In the last few years there have been multiple recalls, some by major toy manufacturers such as Mattel and Fisher-Price, of products manufactured in China that contained unsafe levels of lead.

“Lead is out there, and we need to take precautions, such as making sure we keep kids away from peeling paint and make sure they practice good hand washing before they eat if they are playing in the soil,” Froehlich said.

In addition, good nutrition, including making sure children have adequate levels of iron and calcium, can also protect from lead exposure. Children with iron and calcium deficiencies absorb more lead than children with better diets, Froehlich explained.

Report questions value of family health history

January 30th, 2010

Getting a patient’s family history is widely regarded as a standard element of good medical care. But a report published today concludes that there isn’t much good evidence that obtaining such information improves doctors’ ability to predict and manage disease.

In addition, the report’s authors say the best way to collect family history data is unclear, as is the impact on patient outcomes and behaviors.

Dr. Brenda J. Wilson, from University of Ottawa, Ontario, Canada and colleagues did a study of previous studies on the subject, and report their findings in the online version of the Annals of Internal Medicine.

They found only two studies that tried to determine whether accurate family histories were likely to have an impact on care, and those studies had a number of limitations.

They found more studies of how patients reported their family histories. In 23 studies, they saw evidence that patients were more accurate about reporting the absence of disease in relatives than the presence of disease. Perhaps not surprisingly, patients were more accurate about their first degree relatives than their distant relatives.

The study was funded by the Agency for Healthcare Research and Quality.

Restless Legs May Vary by Race and Gender

January 24th, 2010

Restless legs syndrome, a neurological disorder characterized by a strong urge to move the legs, is much more common among some racial groups than others, a new U.S. study has found.

Researchers interviewed 190 people being seen at a primary care clinic. About 12 percent of those who were black, compared with 36 percent of those who were not black, were found to have restless legs symptoms. Overall, the prevalence of restless legs was 23 percent among the clinic participants.

Among blacks, the prevalence of restless legs syndrome (RLS) was 12 percent for both men and women, compared with 40 percent for women and 29 percent for men among the others, most of whom were white.

“There are significant ethnic differences in the prevalence of restless legs syndrome, but the exact causes of higher prevalence among Caucasians are unknown,” study author Dr. Ammar Alkhazna, of the University of Missouri, said in a news release from the American College of Chest Physicians. “This likely reflects a combination of factors, including a genetic predisposition to RLS, diet, including iron intake, medications, and possibly culture.”

The study was scheduled to be presented at the annual scientific meeting of the American College of Chest Physicians, held Oct. 31 to Nov. 5 in San Diego.

Symptoms of restless legs also were seen more often in women than men, the study found.

“Some risk factors for restless legs syndrome appear to be more common among women,” Alkhazna said. “Women are more likely to be iron-deficient than men and have rheumatoid arthritis, which are known risk factors for RLS.”

TV May Increase Aggression in Toddlers

January 17th, 2010

Yet another study has found that television viewing is linked to aggression in young children.

This research, published in the November issue of the Archives of Pediatrics & Adolescent Medicine, found that direct TV watching by young children or exposure to indirect viewing in the household were both associated with increased aggression in small children.

After controlling the data for other factors, such as maternal depression, living in an unsafe neighborhood and being spanked, “for every hour that a child watched TV directly, aggression went up 0.16 on a scale of zero to 30. For a TV being on in the house, it was 0.09,” said study author Jennifer A. Manganello, an assistant professor of health communication at the University of Albany School of Public Health, State University of New York.

And, she said, while the increase may not seem like a lot, when the researchers looked at all of the other factors, “TV was more likely than some other factors to increase aggressive behaviors.”

The American Academy of Pediatrics (AAP) is concerned enough about the media’s effect on children’s behavior that they recently updated their policy on media violence.

“Exposure to violence in media, including television, movies, music and video games, represents a significant risk to the health of children and adolescents. Extensive research evidence indicates that media violence can contribute to aggressive behavior, desensitization to violence, nightmares and fear of being harmed,” wrote the AAP Council on Communications and Media.

For the current study, Manganello and her colleagues collected data from the home and by telephone for 3,128 children born between 1998 and 2000. The children came from 20 large U.S. cities, and their mothers completed surveys when the child was born, and again at ages 1 and 3.

Because so many factors can influence a child’s behavior, the researchers tried to control for as many factors as they could, including maternal health and depression, maternal parenting attitudes and behaviors, maternal experience with violence, the safety of the neighborhood and demographic characteristics.

The researchers found that children who were spanked, lived in an unsafe neighborhood or had a mother who was depressed or stressed were more likely to exhibit aggressive behaviors.

But, after controlling for these and other factors, the study authors found that TV — both direct and indirect viewing — had a statistically significant effect on children’s aggressive behavior.

“A take-home message from this study is that parents should think about how much TV kids are watching themselves, but also think about the overall media environment in the home,” said Manganello.

“TV is not a benign influence. It does have impact,” said Richard Gallagher, director of the Parenting Institute at the New York University Child Study Center in New York City. And, while content may impact children, he pointed out that children’s behaviors may also be affected by the “opportunities lost.”

That means that when a child is watching TV, which is a passive behavior, the child doesn’t have the opportunity to interact with other people and may have reduced contact with his or her peers.

“The AAP guidelines that children under 2 shouldn’t watch any TV may be fairly strict and hard to carry out, but parents should be judicious about how much TV young children are watching, and be aware that it’s not likely to be appropriately stimulating,” he said.

He added that parents need to act as a TV filter for their children. For example, he said, parents should point out when something is silly on TV that it’s not a real-life scenario. Or, if they see something violent — say an anvil dropping on someone’s head in a cartoon — parents need to interpret that for their children, and let them know what would happen if that were a real situation.

Two U.S. deaths possible in beef recall

January 11th, 2010

An outbreak of food-borne illness, linked to dangerous bacteria in ground beef, sickened 28 people and caused at least one death, the U.S. Centers for Disease Control and Prevention said on Monday.

The CDC said a New York adult with underlying medical conditions had died and another possibly related death in New Hampshire was under investigation. State officials attribute the New Hampshire death to the O157:H7 E. coli bacteria.

All but three of the 28 cases listed by the CDC were in the U.S. Northeast and 18 were in the New England states. Sixteen hospitalizations were reported, said a CDC spokeswoman. The bacteria involved were from a common strain, so tests were under way to see if all of the reported cases were related.

Over the weekend, Fairbank Farms of Ashville, New York, recalled 545,699 lbs (248,450 kg) of ground beef products.

The Agriculture Department, which oversees meat safety, said an investigation led it to conclude “there is an association between the fresh ground beef products and illnesses in Connecticut, Maine and Massachusetts.” USDA worked with state and federal officials in examining a cluster of E. coli O157:H7 illnesses.

A potentially deadly bacteria, E. coli can cause bloody diarrhea, dehydration and, in severe cases, kidney failure. The very young, the elderly and people with weak immune systems are the most susceptible to foodborne illness.

A string of food-borne safety scares led the U.S. House of Representatives to pass legislation this summer to require more inspections and oversight of food manufacturers and would give the government new authority to order recalls.

Fairbank Farms announced the recall on Saturday. The beef was produced in mid-September and probably was labeled for sale before the end of the month, said USDA.

It went to retailers including Trader Joe’s, Price Chopper, Lancaster and Wild Harvest, Shaw’s, a unit of Supervalu, BJ’s, Ford Brothers and Giant, a unit of Ahold, in eight states — Connecticut, Maryland, Massachusetts, New Jersey, New York, North Carolina, Pennsylvania and Virginia.

Skinny friends may make you eat more

December 28th, 2009

That friend who stays thin despite eating anything and everything is not just annoying. She might also wreck your diet, new research suggests.

Researchers found that when they had college students watch a movie and snack with either a skinny or overweight companion, the students typically followed the thin friend’s lead when she overindulged.

In contrast, study participants used more self-control when snacking with a heavier companion who overate.

The findings, published in the Journal of Consumer Research, suggest that seeing a thin friend devour a big meal gives us implicit permission to do the same.

“We think ‘if she can eat like that and stay thin, so can I,’ or ’she is having cake, then I can too,’” explained Dr. Brent McFerran, an assistant professor of marketing at the University of British Columbia in Kelowna, Canada.

“In other words,” he told Reuters Health in an email, “the most dangerous person to eat with is not someone who is obese, but a thin friend with a large appetite.”

For their study, McFerran and his colleagues recruited 210 female college students for what the participants believed was a study on movie viewing; each woman watched a movie with a companion, who was actually a member of the research team.

In some cases, the researcher showed up as her normal 105-pound self, while in others she donned padding that made her appear to be obese.

During the movie, the pairs were offered snacks, with the undercover researcher taking her portion first.

In general, McFerran’s team found, the students ate more when their thin companion took a large portion, versus cases where the “obese” companion took a similarly large portion.

For example, when the skinny researcher ate a lot (30 candies), the participants ate an average of 10 candies. When the researcher was “obese” and ate a lot, the kids ate about 6 candies.

“Eating involves much social pressure,” McFerran said, noting that social influences may, in fact, be the strongest predictor of what we eat.

But the current findings do not mean that we need to cancel all future dinner plans with our overindulgent skinny friends.

“If we think about what we are doing in advance,” McFerran said, “we are less likely to overconsume.”

He suggested that instead of looking at a thin friend who is gorging on dessert and feeling permission to do the same, we should remind ourselves that individuals are different — with different metabolisms and exercise habits, for example.

Focus on your own goal to eat healthfully, McFerran said, rather than automatically mimicking a friend.

He pointed out, however, that there is a “flip side”: Friends who choose smaller portion sizes and healthier foods can encourage us to do so, especially if those friends are thin.

Autumn Chores Often Hazardous

December 21st, 2009

Taking health and safety precautions when raking leaves, cleaning gutters and performing other outdoor chores can help prevent injuries, according to the American Academy of Orthopaedic Surgeons (AAOS).

“Many people work vigorously in the yard during the autumn season, and it often takes a toll on your body,” AAOS spokesman Dr. Laurence Laudicina, said in a news release from the academy. “Raking leaves and cleaning out the gutters are popular seasonal chores that can lead to falls or strain to your back and upper body.”

In 2008 in the United States, about 617,000 people suffered injuries caused by rakes, other outdoor garden supplies and ladders, the U.S. Consumer Product Safety Commission noted.

So to help avoid becoming one of those statistics, the AAOS offers the following autumn chore safety tips:
Warm up for at least 10 minutes with some stretching and light exercise before beginning work in the yard.
Use a rake that’s comfortable for your height and strength. You can prevent blisters by wearing gloves or using a rake with a padded handle.
Make sure that hats or scarves don’t block your vision, and watch out for large rocks, low branches, tree stumps or uneven surfaces.
Vary your movements and alternate your leg and arm positions often. When picking up leaves, bend at the knees, not at the waist.
Wear shoes or boots with slip-resistant soles.
Don’t overfill leaf bags, especially if the leaves are wet. You should be able to carry bags comfortably.
Don’t throw leaves over your shoulder or to the side. That kind of twisting motion places undue stress on your back.
Inspect ladders for loose screws, hinges or rungs, and make sure it is free of mud, dirt or liquids.
Make sure all ladder legs rest on a firm, level surface. Don’t use ladders on uneven ground or soft, muddy earth.
Always face a ladder when climbing and descending.
Confirm that the ladder is fully open and locked before you climb it.
Angle ladders about 75 degrees from the ground.
Don’t sit or stand on the top of the ladder or on its pail shelf.
Use the right ladder for the job. Step stools or utility ladders are good for working at low or medium heights, while extension ladders should be used outdoors to reach high places.

Antidepressants Linked to Heart Defects in Newborns

December 15th, 2009

Women who take certain antidepressants during the first three months of pregnancy may have a slightly increased risk of giving birth to babies with heart defects.

Septal heart defects — malformations in the wall separating the right side of the heart from the left — were more common among women taking antidepressants in the first trimester, Danish researchers found. Some of these heart defects resolve on their own, while others require surgery.

The risks were seen in sertraline (trade names Zoloft and Lustral) and in citalopram (Celexa), both of which belong to the class of medications known as selective serotonin reuptake inhibitors (SSRIs).

Women who took more than one SSRI early in their pregnancy had a fourfold higher risk of having babies with this problem, said the authors of a study appearing online Sept. 24 in BMJ.

Still, the authors said the absolute risk is relatively low: 246 women would have to take such medication in order to see one septal heart defect. And 62 mothers would have to take more than one SSRI to see a problem in one child.

“A potential association with malformations must be considered in the choice of treatment of depression during pregnancy,” said Dr. Lars Henning Pedersen, lead author and a research assistant in the department of epidemiology at Aarhus University in Denmark. However, “if our data is correct, the absolute risk is low, which must be balanced against the potential substantial risk of under- or untreated depression during pregnancy.”

Other experts agree. “Early exposure can slightly increase the risk of heart defects, but the overall risk is still very, very small,” added Dr. Jennifer Wu, an obstetrician and gynecologist at Lenox Hill Hospital in New York City.

And discontinuing antidepressants also carries risks.

“The concern with pregnant women with depression, if you take them off their medication, they can have a relapse into severe depression and this could lead to self-destructive behaviors,” Wu said.

Previous studies have found that pregnant women who stopped taking their antidepressant medications were five times more likely to relapse than women who continued with the medication.

In the United States, 13 percent of women have taken an antidepressant while pregnant, according to an accompanying editorial.

Recent research has indicated a higher risk of various defects, including heart defects, among pregnant women taking antidepressants, and the U.S. Food and Drug Administration and the American College of Obstetricians and Gynecologists (ACOG) have issued warnings about possible birth defects associated with the use of the SSRI Paxil (paroxetine) by moms-to-be.

But existing studies have yielded conflicting results about dangers associated with specific drugs.

These researchers looked at almost 500,000 children born in Denmark between 1996 and 2003, a time when the number of pregnant women taking antidepressants quadrupled.

Although no overall association was found in this study between mothers taking SSRIs during the first trimester and birth defects in general, there was a doubling in the risk for septal heart defects for women using Zoloft and Celexa, but not Prozac (fluoxetine) or Paxil.

Pedersen recommended more and larger studies to explore the matter.

In August, the American Psychiatric Association in collaboration with ACOG recommended that women with major depression who are pregnant or planning to get pregnant can start or continue with antidepressant drugs, while women who choose to stop taking the drugs should consider psychotherapy.

“Ideally, you’d want to work closely with a psychiatrist and ob/gyn when planning a pregnancy,” Wu said. “When you are suddenly pregnant, there’s a lot of anxiety involved and other hormones, so it’s probably not a good time at that point to try to go off medications, and it certainly should be supervised.”

Patients who are relatively stable, on the other hand, could consider going off their medications for the first trimester, knowing that it will take four-to-six weeks for the drug effect to wear off and also knowing that the medications would be resumed at the first sign of a relapse, Wu said.

Exercise May Prevent Prostate Cancer: Study

December 7th, 2009

Regular exercise may help protect men from prostate cancer, says a new study.

U.S. researchers looked at 190 men who had a prostate biopsy and found that those who were moderately active — anything equivalent to walking at a moderate pace for several hours a week — were significantly less likely to be diagnosed with prostate cancer.

The study also found that exercise was associated with less aggressive disease in men who did develop prostate cancer.

“As the amount of exercise increased, the risk of cancer decreased,” lead author Dr. Jodi Antonelli, a urology resident at Duke University Medical Center, said in a news release.

The results, published Sept. 22 online in the Journal of Urology, contribute to the ongoing debate about how exercise affects prostate cancer risk, said study senior author Dr. Stephen Freedland, a urologist at Duke and the Durham Veterans Affairs Hospital.

“There have been dozens of studies about the value of exercise in lowering risk of prostate cancer, and some of them quite large, but the bottom line is that they’ve left us with mixed signals,” Freedland said in the news release.

The majority (58 percent) of the men in this study were sedentary, which means they exercised less than the equivalent of one hour per week of easy walking.

Newer Drug Beats Tamoxifen for Older Breast Cancer Patients

November 25th, 2009

For postmenopausal women with breast cancer, treatment with the drug letrozole (Femara) increases survival after surgery more than the widely used tamoxifen, a new study confirms.

Both letrozole and tamoxifen have been used to prevent recurrence of breast cancer in postmenopausal women with hormone receptor-positive cancer, but whether one drug is better than the other has been unclear. The new study compared the impact of the newer drug, letrozole, to tamoxifen.

“This study reinforces the benefits of letrozole over tamoxifen, and leaves five years upfront use [of letrozole] as the preferred option, especially in patients judged to be at higher risk for recurrence,” said lead researcher Dr. Alan Coates, co-chair of the scientific committee of the International Breast Cancer Study Group and a clinical professor in the School of Public Health at the University of Sydney, Australia.

The report is published in the Aug. 20 issue of the New England Journal of Medicine.

For the study, Coates and colleagues randomly assigned more than 8,000 postmenopausal women with hormone receptor-positive breast cancer to treatment with tamoxifen or letrozole for five years. In addition, some of the women were assigned to switch medicines after two years.

The study shows strong, though not incontrovertible, evidence that letrozole prolongs overall survival in comparison to tamoxifen, and that “this would in all probability have been conventionally significant had the switch of therapy not occurred,” Coates said.

The other question in the study was whether the letrozole should be given before or after a period of tamoxifen therapy, Coates said.

“Neither sequence was superior to five years of straight letrozole,” he said. “We found that the differences were small, but that consistently in the higher risk subgroups there was a benefit to starting with letrozole.”

The study also included starting with letrozole and switching to tamoxifen, Coates noted.

“The difference between straight letrozole and the reverse sequence was very small in all groups, which will be reassuring to those women who, having started adjuvant treatment with letrozole, are obliged for any reason to discontinue that drug. Our data suggest that they can safely switch to tamoxifen if required with little or no harm to their prognosis,” he said.

Both drugs are used after initial treatment to prevent the cancer from returning. The medications work by preventing the production or activity of estrogen, which is associated with breast cancer recurrence in postmenopausal women. The drugs work differently, which may account for the benefit of letrozole over tamoxifen. Letrozole is from a class of drugs called aromatase inhibitors, which block the production of estrogen. Tamoxifen differs in that it interferes with the activity of estrogen, not the hormone’s production.

Dr. Victor Vogel, national vice president of research at the American Cancer Society, believes that because letrozole is more effective and has fewer side effects than tamoxifen, it should be used for most patients.

“The message to lay people is letrozole is better. That’s the unequivocal, unconfused message,” Vogel said. “If you are a postmenopausal women taking tamoxifen for early breast cancer, it’s probably a good idea to switch from tamoxifen to letrozole.”

However, tamoxifen should be used for patients who find it difficult to take letrozole, Vogel said. “Somewhere between 15 and 25 percent of patients get significant muscle aches and joint aches with aromatase inhibitors. For those patients, tamoxifen is still a reasonable thing to do.”

Dr. Larry Norton, deputy physician-in-chief of Breast Cancer Programs at Memorial Sloan-Kettering Cancer Center in New York City, said the study shows no advantage in starting women on tamoxifen and then switching them to letrozole.

“For postmenopausal people, it becomes clearer and clearer that the treatment of choice is an aromatase inhibitor without the use of tamoxifen,” Norton said. “The window of opportunity for tamoxifen is narrowed by this paper.”

“For most patients who are postmenopausal, I use an aromatase inhibitor exclusively,” Norton added. “But I have used tamoxifen in postmenopausal patients for specific situations, such as extremity fragile bones, or such as intolerance of the aromatase inhibitor.”